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Cardiac function in hereditary transthyretin amyloidosis - DiVA

Symptoms of heart disease are generally more severe in patients with AL amyloidosis than in those with ATTR amyloidosis. Symptoms of cardiac amyloidosis. Amyloid deposits in the heart muscle may cause no symptoms at all if they are small. But when amyloid deposits in the heart are large, they can lead to stiffening of the heart muscle. 2020-02-04 · In its early stages, amyloidosis might not cause symptoms.

Eur Heart J. 2017;38(38):2879-2887. 7. AL amyloidosis can cause a number of symptoms and affect the body in several ways. This is because the amyloid protein can be deposited in almost any organ in the body.

Cause and symptoms of hereditary ATTR amyloidosis

ATTR amyloidosis can affect many organs. Symptoms depend on the organs that are involved. Symptoms indicating the arms are affected include: Carpal tunnel syndrome. Numbness, burning and/or tingling (peripheral neuropathy).

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The symptoms of amyloidosis tend to be subtle and will vary depending on where the amyloid protein is collecting. Heart medicines: If amyloidosis has affected your heart, your doctor might include blood thinners to reduce clot risk and medications to control your heart rate. Palpitations of the heart; Based on the organs involved and the resulting symptoms, amyloidosis can cause particular groups of symptoms, referred to by doctors as syndromes. These include: Congestive heart failure, or the inability of the heart to pump enough blood to meet the body's needs. Symptoms can include: General - Fatigue, loss of weight, weakness Cardiac - Shortness of breath, dizziness or feeling faint, exercise intolerance, irregular heart rate, palpitations Neurologic - Numbness or tingling in the hands or feet, painful feet/legs; carpal tunnel syndrome, which causes pain, numbness or tingling in the fingers. ♦ Hereditary amyloidosis: This is the rarest version and is caused by a mutation in a gene that runs in families.

Amyloid deposits in the heart muscle may cause no symptoms at all if they are small. But when amyloid deposits in the heart are large, they can lead to stiffening of the heart muscle. This is called a “restrictive cardiomyopathy”. When the heart muscle is stiff, the heart is unable to pump the blood around the body as efficiently as usual. Symptoms of heart failure may then appear.
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Journal of Internal Medicine.

6. Castaño A, Narotsky D, Hamid N, et al. Unveiling transthyretin cardiac amyloidosis and its predictors among elderly patients with severe aortic stenosis undergoing transcatheter aortic valve replacement. Eur Heart J. 2017;38(38):2879-2887.
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Cause and symptoms of hereditary ATTR amyloidosis

Most people with AL amyloidosis have a build-up of amyloid proteins in their kidneys, and are at risk of kidney failure. Symptoms of kidney failure include: swelling, often in the legs, caused by fluid retention ; tiredness Different mutations lead to different symptoms — some may affect the nerves; some may affect the heart; and some may affect both. Wild-type ATTR amyloidosis. Unlike hereditary ATTR amyloidosis, wild-type does not involve abnormal DNA and cannot be passed on to family members.